As a kind of medical polymer material with excellent performance, silicone rubber has attracted the attention of professionals in both the rubber industry and the medical field. The reason is that, firstly, it is used as rubber medical material with high technical content, low cost, high added value, and considerable economic benefits. Secondly, the medical properties of silicone rubber can solve many problems in medical technology and can also be solved. To enable patients to obtain satisfactory efficacy; Third, rubber sources are extensive, easy to produce and fine processing, with good social and economic benefits.
Silicone rubber has occupied a very important position in the medical field, but if there is greater development, technical problems still need to be resolved.
Since long-term subcutaneous implants using silicone rubber as a carrier must be removed after the expiration of the effective period of placement, the user's pain and costs are increased, and it is difficult to ensure that all users can take out on schedule, thereby increasing the risk of contraceptive failure. This led to the study of biodegradable subcutaneous contraceptive implants, that is, a polymer with biodegradability and steroid drug permeability, instead of silicone rubber as a carrier for the release of progesterone, the progesterone release carrier Degradation and absorption in the body without removing it. The United States Triangle Research Institute has developed a biodegradable subcutaneous contraceptive implant Capronor (effective contraception for one year), its contraceptive efficiency, safety, acceptability and similar to Norplant, capsules remain structural integrity for 18 to 24 months, and then began Deformation, fragmentation and gradual degradation. The Institute of Biomedical Engineering of the Chinese Academy of Medical Sciences changed the formula of capsules on the basis of Ca-pronor to make biodegradable subcutaneous contraceptive implant CaproF. Basic research and animal experiments have now been completed. In short, single-type implants and biodegradable implants are the main research and development directions.
With biomedical engineering. With the development of tissue engineering, the technical and performance requirements for medical materials have increased. In terms of silicone rubber, how to make it fully applied to bio-engineering and tissue engineering is the main direction of future research work. For example, biosensors are a compelling biotechnology today. The miniaturization of biosensors and the adaptability of organisms will become important issues related to artificial organs.
Due to its hydrophobic nature, silicone rubber still has a slight foreign body sensation after it is implanted in the human body. To solve this problem, surface modification methods such as applying a hydrophilic substance to the surface of the silicone rubber article or grafting the surface of the silicone rubber by radiation or plasma treatment or modification by blending may be used.
In short, medical silicone rubber has been widely and importantly applied in the fields of life sciences, medical devices, and drugs, but there is still great potential to be tapped. With the development of life sciences and the research of biological materials, it will be used for human society. Make more contributions.